Glycosylation as an Important Regulator of Antibody Function
نویسندگان
چکیده
منابع مشابه
S100 Proteins As an Important Regulator of Macrophage Inflammation
The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation. The intracellular functions of S100 proteins involve interaction with intracellular receptors, membrane protein recruitment/transporta...
متن کاملInorganic Phosphate as an Important Regulator of Phosphatases
Cellular metabolism depends on the appropriate concentration of intracellular inorganic phosphate (Pi). Pi starvation-responsive genes appear to be involved in multiple metabolic pathways, implying a complex Pi regulation system in microorganisms and plants. A group of enzymes is required for absorption and maintenance of adequate phosphate levels, which is released from phosphate esters and an...
متن کاملFunction and glycosylation of plant-derived antiviral monoclonal antibody.
Plant genetic engineering led to the production of plant-derived mAb (mAbP), which provides a safe and economically feasible alternative to the current methods of antibody production in animal systems. In this study, the heavy and light chains of human anti-rabies mAb were expressed and assembled in planta under the control of two strong constitutive promoters. An alfalfa mosaic virus untransla...
متن کاملAntibody Glycosylation and Inflammation
IgG antibodies are the basis of some of the most effective therapeutics developed over the last 20 years. These antibodies are highly specific, have long serum-half lives, and can be produced relatively routinely, making them ideal drugs for immunotherapy. The degree of regulation on IgG antibody effector functions by the composition of the single, N-linked glycan attached to the Fc is increasi...
متن کاملFertilization promoting peptide: an important regulator of sperm function in vivo?
Fertilization promoting peptide (FPP; pGlu-Glu-ProNH2), a tripeptide structurally related to thyrotrophin releasing hormone, is produced by the prostate gland and released into seminal plasma. Recent studies carried out in vitro have revealed that FPP elicits biologically important responses in both mouse and human spermatozoa. In the presence of physiological concentrations of FPP (50-100 nmol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Klinicka Onkologie
سال: 2019
ISSN: 0862-495X,1802-5307
DOI: 10.14735/amko20193s46